The stromal-vascular fraction (SVF) is a unique cell complex derived from the patient’s own adipose tissue, separated from structural elements and fat cells.

SVF contains mesenchymal stromal cells of adipose tissue unique for each person. These cells are able to turn at the place of use into those cells that the body needs (cartilage, bone, muscle, nerve, liver, heart muscle). In addition to mesenchymal stromal cells, SVF also includes a group of mature cell precursors and mature cells themselves. All these cells positively affect the formation of new blood vessels, the growth of new cells at the injection site and contribute to the reduction of inflammation.

SVF contains:

Pericytes

The cells surrounding the blood capillaries and part of their walls, pericytes affect the proliferation of endotheliocytes

Pericytes

Adipose Stem Cells

Poorly differentiated (cambial) cells accompanying small blood vessels. These cells, through divergent differentiation, give rise to various cellular differentials (fibroblastic, myofibroblastic, adipocytic, etc.)

Adipose Stem Cells

Endothelial cells

Contribute to angiogenesis with the introduction of the graft

Endothelial cells

White blood cells

Cells that provide specific and non-specific protection. So SVF can be used during an active inflammatory response due to the presence of leukocytes in its composition

White blood cells

Red blood cells

Highly differentiated cells responsible for the transport of oxygen and carbon dioxide, amino acids, antibodies, toxins and a number of drugs, adsorbing them on the surface of the plasma membrane

Red blood cells

Smooth muscle cells of blood vessels

Cells that contribute to atherogenesis with the introduction of the graft

Smooth muscle cells of blood vessels

Endothelial Cell Precursors

Cells that contribute to the restoration of the endothelial layer and the maintenance of its normal function

Endothelial Cell Precursors

Advantages of SVF

стандартная процедура
standard
procedure
местная анастезия
local
anesthesia
минимальная травматичность
minimal trauma for the patient
процедура делается в течение одного дня пребывания в стационаре
the procedure is done within one day in hospital
The source of SVF is adipose tissue. Its main advantage, as a source for obtaining cells, is the relative simplicity of cell collection - liposuction, which is widespread in aesthetic medicine. The procedure is standardized, easy to perform and can be performed under local anesthesia. To obtain a sufficient amount of SVF, only 50 to 200 ml of adipose tissue will be needed, which will not require serious surgical intervention.

Areas of application:

Endocrinology

Restoration of damaged ligaments and articular cartilage

Aesthetic medicine

Treatment of postoperative scars, scars, alopecia, pigmentation, scleroderma, as well as age-related

Regenerative surgery

Treatment of burns, trophic ulcers, autologous transplantation of SVF with neurotization of the muscular-cutaneous nerve

Gynecology

Treatment of recto-vaginal fistula

Plastic and reconstructive surgery

In the enrichment of lipoaspirate, for the correction of soft tissue defects, for example, dysplasia, post-traumatic and postoperative defects and for aesthetic purposes to improve the condition of the skin

Urology

Treatment of erectile dysfunction, urinary incontinence

Traumatology

Restoration of damaged ligaments and articular cartilage

Coloproctology

Treatment of fistulas in Crohn’s disease

Pulmonology

Treatment of idiopathic pulmonary fibrosis

Interventional cardiology

Restoration of the heart muscle in acute myocardial infarction, chronic heart failure

Orthopedics

Supplementation of SVF autologous plastics in post-traumatic recovery of peripheral nerves

Abdominal surgery

Treatment of fistulas in Crohn’s disease

For the first time, SVF was used in reconstructive plastic surgery. The feasibility of obtaining mesenchymal stromal cells from adipose tissue was demonstrated in 2001. With this discovery, the active development of a new direction in medicine began - autologous transplantation of SVF in various pathologies. Due to the cellular composition, SVF has a wide range of beneficial effects on the body and can be used in almost all areas of medicine. To date, the use of SVF has found wide application in plastic and reconstructive medicine, orthopedics, traumatology, urology.

In plastic surgery and reconstructive medicine, SVF is used in the enrichment of an autograft, for the correction of soft tissue defects, dysplasia, post-traumatic and postoperative defects, for aesthetic purposes to improve the condition of the skin. This method allows you to minimize the resorption of the introduced adipose tissue and its replacement with its fibrous tissue over time - the formation of scars. In traumatology, with the help of SVF, damaged ligaments and cartilage tissue of articular surfaces are restored. In urology, SVF is used to treat erectile dysfunction and urinary incontinence. In gynecology, with the help of SVF, such a complex pathology as the closure of cysto-vaginal and recto-vaginal fistulas is solved. Soft tissue regeneration is used in almost all areas of medicine. SVF takes central place in a growing range of applications in regenerative medicine.

Countries actively using SVF in medicine: