ESVIEF System is the kit for SVF isolation consisting of a disposable separator and an enzyme – collagenase for the destruction of adipose tissue.
The ESVIEF separator is a high-tech, reliable, safe and easy-to-use device for concentrating SVF from adipose tissue. Enzyme Collagenase NB 6 GMP Grade of the German manufacturer Nordmark Arzneimittel GmbH & Co. KG is manufactured in a facility that meets GMP requirements under aseptic conditions. The enzyme passes high-level quality control in accordance with the requirements of the European Pharmacopoeia, which guarantees the safety of its use.

SVF Stromal-vascular fraction


The stromal-vascular fraction (SVF) is a unique cell complex derived from the patient’s own adipose tissue, separated from structural elements and fat cells. SVF contains mesenchymal stromal cells of adipose tissue unique for each person. They are able to turn at the place of use into those cells that the body needs at the moment (cartilage, bone, muscle, nerve, liver, heart muscle cells). In addition to mesenchymal stromal cells, SVF also includes a group of mature cell precursors and mature cells themselves. This whole complex has a positive effect on the formation of new blood vessels, the growth of new cells at the injection site and contribute to the reduction of inflammation.


The introduction of SVF into the patient’s tissue stimulates local synthesis of growth factors, cytokines, and extracellular matrix elements. This process stimulates neoangiogenesis, affects the modulation of the humoral response, ensures the maintenance of the viability of differentiated cells in the pathological focus. In addition, the introduction of SVF triggers the remodeling of pathologically altered tissues, leading to the induction of differentiation into specialized cells of mesenchymal origin.


SVF can be used in almost all areas of medicine - in plastic surgery and reconstructive medicine, orthopedics, traumatology, urology, coloproctology etc. In traumatology, SVF repairs damaged ligaments and cartilage tissue of articular surfaces. In urology, SVF is used to treat erectile dysfunction and urinary incontinence. In gynecology, with the help of SVF, such a complex pathology as the closure of cysto-vaginal and rectovaginal fistulas is solved. In plastic surgery and reconstructive medicine, SVF is used in the enrichment of lipoaspirate, for the correction of soft tissue defects, dysplasia, post-traumatic and postoperative defects, for aesthetic purposes to improve the condition of the skin.


Today this technology is used in many countries of the world (USA, Japan, South Korea, Czech Republic, France etc.). Moreover, in France and Japan, SVF is part of the government funding program for medical services. Thus, SVF is becoming central in a growing spectrum of applications in regenerative medicine.


The process of working with the ESVIEF system is as standardized as possible, which eliminates the influence of environmental factors on the final result; the protocol does not require specific skills in handling cell cultures from a specialist. The product is intended for professional use in medical institutions. The total time for isolation of SVF using the ESVIEF kit is no more than 2 hours. More


JoinTechCell LLC was established in 2013 as a project company of Nearmedic Group. The organization is focused on the development of medical products in the field of cell technologies for use in regenerative medicine. The flagship product of the company is a separator for obtaining a high-quality cell product - the stromal-vascular fraction of adipose tissue. More

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