The stromal-vascular fraction (SVF) is a unique cell complex derived from the patient’s own adipose tissue, separated from structural elements and fat cells. SVF contains mesenchymal stromal cells of adipose tissue unique for each person. They are able to turn at the place of use into those cells that the body needs at the moment (cartilage, bone, muscle, nerve, liver, heart muscle cells). In addition to mesenchymal stromal cells, SVF also includes a group of mature cell precursors and mature cells themselves. This whole complex has a positive effect on the formation of new blood vessels, the growth of new cells at the injection site and contribute to the reduction of inflammation.
MECHANISM OF ACTION
The introduction of SVF into the patient’s tissue stimulates local synthesis of growth factors, cytokines, and extracellular matrix elements. This process stimulates neoangiogenesis, affects the modulation of the humoral response, ensures the maintenance of the viability of differentiated cells in the pathological focus. In addition, the introduction of SVF triggers the remodeling of pathologically altered tissues, leading to the induction of differentiation into specialized cells of mesenchymal origin.
APPLICATION OF SVF
SVF can be used in almost all areas of medicine - in plastic surgery and reconstructive medicine, orthopedics, traumatology, urology, coloproctology etc. In traumatology, SVF repairs damaged ligaments and cartilage tissue of articular surfaces. In urology, SVF is used to treat erectile dysfunction and urinary incontinence. In gynecology, with the help of SVF, such a complex pathology as the closure of cysto-vaginal and rectovaginal fistulas is solved. In plastic surgery and reconstructive medicine, SVF is used in the enrichment of lipoaspirate, for the correction of soft tissue defects, dysplasia, post-traumatic and postoperative defects, for aesthetic purposes to improve the condition of the skin.
SVF IN THE WORLD
Today this technology is used in many countries of the world (USA, Japan, South Korea, Czech Republic, France etc.). Moreover, in France and Japan, SVF is part of the government funding program for medical services. Thus, SVF is becoming central in a growing spectrum of applications in regenerative medicine.